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The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection Review

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Engineering 2022, Volume 10, Issue 3,   Pages 21-29 doi: 10.1016/j.eng.2021.10.015

Abstract: component of innate immune cells, macrophages are the predominate infiltrated cells in allografts, and macrophageHowever, some macrophage subpopulations, such as regulatory macrophages, can protect allografts fromimmune rejection and promote transplant immune tolerance with their immune regulatory properties.

Keywords： Macrophages     Transplantation     Tolerance     Rejection     Regulatory macrophage    

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract: Moreover, some stem cell-based products have been approved for marketing by different national regulatoryexist and need to be urgently addressed, especially in countries where establishment of appropriate regulatoryMore relevantly, the stem cell regulatory sciences need to be established or improved to more effectivelyevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatoryregulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory

Keywords： cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines     regulatory    

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: Tear film hyperosmolarity plays a core role in the development of dry eye disease (DED) by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium. In this study, the mechanisms involving the hyperosmolar microenvironment, glycolysis mediating metabolic reprogramming, and pyroptosis were explored clinically, in vitro, and in vivo. Data from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genes, including PKM2 and GSDMD, was significantly upregulated and that the secretion of IL-1β significantly increased. In vitro, the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells (HCECs) was used to discuss the interaction among cells. The hyperosmolar environment was found to greatly induce HCECs’ metabolic reprogramming, which may be the primary cause of the subsequent inflammation in macrophages upon the activation of the related gene and protein expression. 2-Deoxy-d-glucose (2-DG) could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosis of macrophages. In vivo, 2-DG showed potential efficacy in relieving DED activity and could significantly reduce the overexpression of genes and proteins related to glycolysis and pyroptosis. In summary, our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis.

Keywords： dry eye disease     glycolytic reprogramming     pyroptosis     inflammation     2-DG    

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Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1402-x

Abstract: Increasingly, 3re implementation is restricted by regulatory difficulties, particularly the invocation

Keywords： Blockchain     E-waste     Regulatory Policy     Copyright Laws     Repair-Reuse-Remanufacture     Toxicity    

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Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1,   Pages 3-15 doi: 10.1007/s11783-014-0734-1

Abstract: This critical review focuses on the issues associated with DBP regulatory compliance, including methodsPrecursor removal and alternative disinfectants are common practices for DBP regulatory compliance.

Keywords： Disinfection byproducts (DBPs)     drinking water standards     regulatory compliance     alternative disinfection    

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: development of genetic sequencing technologies, research on the liver’s cellular composition and its regulatory

Keywords： liver regeneration     hepatocytes     cholangiocytes     stem cells     organoids     regulatory mechanisms     transplantation    

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Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

Engineering doi: 10.1016/j.eng.2023.05.022

Abstract: selective biocatalytic property of macrophages, consisting of an intelligent controlling center (a living macrophage

Keywords： Multidrug-resistant Escherichia coli     Macrophage–Fe3O4@PLGA particles     Biomimetic intelligent catalysis    

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanismThe regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene
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by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Article

Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang

Engineering 2023, Volume 20, Issue 1,   Pages 63-76 doi: 10.1016/j.eng.2021.09.007

Abstract: Transcriptomic profiling suggested that genes related to macrophage function were differently expressedConsequently, the effects of XFBD on macrophage activation and mobilization were investigated in a macrophageXFBD exerts strong inhibitory effects on both macrophage activation and migration.em>, and Citri grandis Exocarpium rubrum, were then found to strongly downregulate macrophageArtemisiae annuae Herba and Ephedrae Herba were found to substantially inhibit endogenous macrophage

Keywords： Xuanfeibaidu Formula     Multimodal identification     Inflammation     Macrophage activation     Macrophage migration    

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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1,   Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract: Regulatory T cells (Tregs) are a subgroup of suppressive CD4+ T cells that play a vital role in the maintenance

Keywords： Regulatory T cells     Cancer     Immunotherapy    

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Frontiers of Agricultural Science and Engineering   Pages 215-230 doi: 10.15302/J-FASE-2021382

Abstract: Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanismThe regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene

Keywords： harvest season     metabolites     tea shoots     transcriptomics     untargeted metabolomics    

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract:

Regulatory science is a discipline that uses comprehensive methods of natural science, social scienceas H1N1 flu, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS), regulatoryIn particular, with the support of research on drug regulatory science, vaccines have played a majorindustry, research and development (R&D) of COVID-19 vaccines in China, and the general state of regulatoryFurther, this review highlights how regulatory science has promoted the R&D of Chinese COVID-19 vaccines

Keywords： Regulatory science     COVID-19 vaccine     Vaccine industry    

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Applications of atomic force microscopy in immunology

Jiping Li, Yuying Liu, Yidong Yuan, Bo Huang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 43-52 doi: 10.1007/s11684-020-0769-6

Abstract: Cellular mechanics, a major regulating factor of cellular architecture and biological functions, responds to intrinsic stresses and extrinsic forces exerted by other cells and the extracellular matrix in the microenvironment. Cellular mechanics also acts as a fundamental mediator in complicated immune responses, such as cell migration, immune cell activation, and pathogen clearance. The principle of atomic force microscopy (AFM) and its three running modes are introduced for the mechanical characterization of living cells. The peak force tapping mode provides the most delicate and desirable virtues to collect high-resolution images of morphology and force curves. For a concrete description of AFM capabilities, three AFM applications are discussed. These applications include the dynamic progress of a neutrophil-extracellular-trap release by neutrophils, the immunological functions of macrophages, and the membrane pore formation mediated by perforin, streptolysin O, gasdermin D, or membrane attack complex.

Keywords： cellular mechanics     atomic force microscopy     neutrophil extracellular trap     macrophage phagocytosis     pore    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract:

Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immuneOne mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signalregulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 188-203 doi: 10.15302/J-FASE-2019307

Abstract: Regulatory policies have stagnated due to legal guidelines that could not anticipate the needs and solutionsI propose a new, market-based regulatory model for GM livestock that has both a strong scientific foundation

Keywords： algorithms     editing     FDA     GMO     recombinant DNA     USDA    

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Title Author Date Type Operation

The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Journal Article

Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Journal Article

Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Journal Article

Liver cell therapies: cellular sources and grafting strategies

Journal Article

Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Journal Article

by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated

Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang

Journal Article

Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy

Feng Xie, Rui Liang, Dan Li, Bin Li

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Journal Article

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

Zhiming Huang, Zhihao Fu, Junzhi Wang

Journal Article

Applications of atomic force microscopy in immunology

Jiping Li, Yuying Liu, Yidong Yuan, Bo Huang

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Journal Article